Steroids and derivatives
Medchemexpress LLC 2-imidazolidinone, 1-phenyl-3-(2-piperidinylmethyl)-, hydrochloride | 1257326-24-1 | 98.3% | 295.81 g/mol | C15H22ClN3O | 100 MG
Dopamine D2 receptor agonist-3 is a small-molecule research compound described as a selective dopamine D2 receptor partial agonist and a dopamine D3 receptor antagonist. Supplied as the hydrochloride salt in solid form, it is intended for in vitro and preclinical receptor pharmacology studies; not for human use.
- Selective D2 partial agonist (pEC50 = 8.3)
- D3 antagonist activity (pEC50 < 5.5)
- Molecular formula C15H22ClN3O; molecular weight 295.81 g/mol
- Purity ≥ 98.3% (LCMS)
- Supplied as hydrochloride salt, solid form
- Available in milligram pack sizes for research use
- Intended for in vitro and preclinical research; not for human use
Medchemexpress LLC HY-32339 1mg Medchemexpress, Maxacalcitol CAS:103909-75-7 Purity:>98%
Medchemexpress, HY-32339 1mg Maxacalcitol CAS:103909-75-7 Maxacalcitol (22-Oxacalcitriol) is non-calcemic vitamin D3 analog and ligand of VDR-like receptors. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Palonosetron-d3 hydrochloride | 1246816-81-8 | C19H22D3ClN2O | 1 MG
Palonosetron-d3 hydrochloride is the deuterium-labeled Palonosetron hydrochloride. Palonosetron hydrochloride acts as a 5-HT3 antagonist, primarily utilized for the prevention of acute, delayed, and overall chemotherapy-induced nausea and vomiting. Additionally, it exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron hydrochloride also has antidepressant activity.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Cambridge Isotope Laboratories Acephate (methoxy-D3 thiomethoxy-D3 98%) 100 ug/mL in acetonitrile-D3 1 2 mL
Acephate (methoxy-D3 thiomethoxy-D3 98%) 100 ug/mL in acetonitrile-D3 1 2 mL
Cambridge Isotope Laboratories 25-Hydroxyvitamin D2 (unlabeled) 5 ug/mL in ethanol 1 mL
25-Hydroxyvitamin D2 (unlabeled) 5 ug/mL in ethanol 1 mL
Medchemexpress LLC 1-Methylinosine-d3 (N1-Methylinosine-d3) | 2140-73-0 | 99.0% | 285.27 | 10 MG
1-Methylinosine-d3 is the deuterium-labeled form of 1-Methylinosine. 1-Methylinosine is a modified nucleotide found at position 37 in tRNA, located 3' to the anticodon of eukaryotic tRNA. Deuterium labeling, as seen in this compound, has gained attention for its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- It can be used as a tracer in research applications.
- It serves as an internal standard for quantitative analysis using techniques like NMR, GC-MS, or LC-MS.
- Stable heavy isotopes, such as deuterium, are incorporated into drug molecules for quantitation during drug development.
Medchemexpress LLC Guaiacol-d3 | 74495-69-5 | 127.16 | 50 MG
Guaiacol-d3 is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Cortodoxone-d2 | 1271728-08-5 | 99.0% | C21H28D2O4 | 1 MG
Cortodoxone-d2 is a deuterium labeled glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone). It is suitable for use as a tracer or an internal standard for quantitative analysis in various analytical techniques.
- Can be used as a tracer.
- Acts as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes as tracers for quantitation in drug development.
- Deuteration offers potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC HY-10001 5mg Medchemexpress, Calcipotriol CAS:112965-21-6 Purity:>98%
Medchemexpress, HY-10001 5mg Calcipotriol CAS:112965-21-6 Calcipotriol is a synthetic VitD 3 analogue with a high affinity for the vitamin D receptor. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Dopamine D2 receptor agonist-3 | 1257326-24-1 | 98.3% | 295.81 | C15H22ClN3O | 5 MG
Dopamine D2 receptor agonist-3 is a small-molecule research compound that acts as a selective dopamine D2 receptor partial agonist and a dopamine D3 receptor antagonist, with reported in vitro potency and demonstrated brain penetration in vivo. It is supplied as a solid (white to off-white) with high stated purity for laboratory use.
- Selective D2 partial agonist and D3 antagonist activity.
- Potency reported as pEC50 D2 = 8.3; D3 < 5.5 (approx. D2 EC50 ≈ 5 nM).
- Demonstrated brain penetration (brain:blood ratio 5.5; Tmax 0.5 h at 3 mg/kg, s.c.).
- High purity (98.3%) suitable for research applications.
- Solid, white to off-white appearance, available in small research pack sizes.
Medchemexpress LLC Nudifloramide-d3 | 1207384-48-2 | 99.4% | 155.17 | 1 MG
Nudifloramide-d3 (2PY-d3) is a deuterium labeled Nudifloramide. It is an end product of nicotinamide-adenine dinucleotide (NAD) degradation and significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro. Deuteration, the incorporation of stable heavy isotopes, allows it to be used as a tracer during drug development, affecting pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Melatonin-d3 (N-acetyl-5-methoxytryptamine-d3) | 90735-69-6 | 99.2% | C13H13D3N2O2 | 1 MG
Melatonin-d3 is a deuterium-labeled form of Melatonin, a hormone produced by the pineal gland. Melatonin activates melatonin receptors and is known for its role in sleep, as well as its significant antioxidative and anti-inflammatory properties. It has been identified as a novel selective ATF-6 inhibitor and can induce apoptosis in human hepatoma cells by downregulating COX-2. Additionally, Melatonin has been shown to attenuate palmitic acid-induced mouse granulosa cell apoptosis through endoplasmic reticulum stress.
- Deuterium labeled
- Tracer
- Internal standard for quantitative analysis
- Pharmacokinetic studies
Sigma Aldrich Fine Chemicals Biosciences 24R2425 Dihydroxyvitamin D
(24R)-24 25-Dihydroxyvitamin D3 is a metabolite of vitamin D3. It is known to increase bone volume and mechanical strength.(24R) 24 25-Dihydroxyvitamin D3-26 26 26 27 27 27-d6nbspis a deuterated metabolite of vitamin D3 wherein methyl protons of C-26 C-27 carbons are replaced by deuterium.
Medchemexpress LLC D3/5-HT receptor modulator-1 | 898532-85-9 | 391.51 | 1 ML
D3/5-HT receptor modulator-1 (compound 5i) is a selective dopamine D3 receptor and 5-HT2A receptor antagonist and a partial 5-HT1A receptor agonist. It has a low affinity for dopamine D2 receptors, 5-HT2C receptors, and hERG channels, and presents an atypical antipsychotic profile.
- Selective dopamine D3 receptor and 5-HT2A receptor antagonist.
- Partial 5-HT1A receptor agonist.
- Shows Ki values of 4.5 nM (D3), 11.9 nM (5-HT2A), and 15.3 nM (5-HT2A).
- Low affinity for dopamine D2 receptors, 5-HT2C receptors, and hERG channels.
- Atypical antipsychotic profile.
Medchemexpress LLC Verapamil-d3 hydrochloride | 2714485-49-9 | 99.57% | C27H36D3ClN2O4 | 5 MG
Verapamil-d3 hydrochloride is the deuterium labeled Verapamil hydrochloride. Verapamil hydrochloride is a calcium channel blocker and a potent, orally active first-generation P-glycoprotein (P-gp) inhibitor. It also inhibits CYP3A4 and has potential for research into high blood pressure, heart arrhythmias, and angina.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development
- Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs