Steroids and derivatives
Sigma Aldrich Fine Chemicals Biosciences Cholecalciferol | 67-97-0 | MFCD00078131 | 5X30MG
Cholecalciferol | Mol Wt: 384.64 | 67-97-0 | MFCD00078131 | 5X30MG
Arbor Assays 20-Hydroxyecdysone ELISA Kit (5 Plate)
The DetectX 20-Hydroxyecdysone ELISA Kits measure 20-hydroxyecdysone in arthropods and plants.
Selleck Chemical LLC Paricalcitol-1mg
Paricalcitol (Paracalcin, Zemplar, 19-Nor-1-25-OH2D2, 19-Nor-colecalciferol) is a selective vitamin D receptor agonist. Paricalcitol suppresses parathyroid hormone mRNA expression and inhibits parathyroid cell proliferation. Pariccitol is used to treat secondary hyperparathyroidism in chronic kidney disease.
Cambridge Isotope Laboratories GLYCOCHOLIC ACID (2,2,4,4-D4, 98%) (CONTAINS ~4% WATER), 10 MG
GLYCOCHOLIC ACID (2,2,4,4-D4, 98%) (CONTAINS ~4% WATER), 10 MG
Sigma Organic Chemistry 1-Butyl-3-methylimidazolium acetate | 50G | 284049-75-8 | MFCD06798175 | >=96.0% (HPLC)
1-Butyl-3-methylimidazolium acetate | 50G | 284049-75-8 | MFCD06798175 | >=96.0% (HPLC)
MOLECULAR DEPOT LLC 25-OH Vitamin D3 Biotin - 1 mg
25-OH Vitamin D3 Biotin Conjugate consists of 25-OH Vitamin D3 conjugated to Biotin via a 22 A spacer arm The spacer adds flexibility to the 25-OH Vitamin D3 moiety which is required for its interaction with specific antibodies and other binding partners This compound has been tested for use in several 25-OH Vitamin D applications including ELISA The conjugate is supplied as a DMSO stock solution For in vitro research use only
Selleck Chemical LLC Cortisone
Cortisone is a pregnane steroid hormone and one of main substance released by the body as a reaction to stress It suppresses the immune system thus reducing inflammation and attendant pain and swelling at the site of the injury
Apexbio Technology LLC Medroxyprogesterone acetate 71-58-9 10mM (in 1mL DMSO)
Medroxyprogesterone acetate (MPA) is a synthetic steroidal derivative structurally related to the endogenous hormone progesterone classified as a progestin Acting primarily through binding to progesterone receptors it modulates gene transcription influencing endometrial proliferation and reproductive pathways Additionally MPA exhibits affinity toward glucocorticoid receptors which may contribute to its physiological effects In biomedical research MPA serves as a standard experimental tool to investigate progesterone receptor signaling mechanisms and steroid hormone interactions Furthermore it is widely used in studies focused on reproductive biology contraceptive mechanisms hormone replacement therapy models oncology research involving hormone-responsive tumors and conditions such as endometriosis
Apexbio Technology LLC Prednisone 53-03-2 1g
Prednisone is a synthetic glucocorticoid which functions primarily as an agonist of the glucocorticoid receptor (GR) Upon binding to the GR prednisone induces receptor translocation into the nucleus initiating the regulation of gene expression involved in inflammation immune responses and cellular proliferation Due to its immunosuppressive mechanism prednisone is widely used as an experimental tool in biomedical studies exploring inflammatory diseases autoimmune conditions and immune signaling pathways Structurally prednisone is a corticosteroid derivative characterized by specific modifications that affect its pharmacodynamics and bioavailability In laboratory settings prednisone assists researchers in dissecting glucocorticoid-mediated physiological and molecular events evaluating receptor-ligand interactions and examining downstream signaling mechanisms in various cell-based assays and animal models
Apexbio Technology LLC Dexamethasone acetate 1177-87-3 10mM (in 1mL DMSO)
Dexamethasone acetate a synthetic glucocorticoid acts by binding to glucocorticoid receptors influencing gene transcription to suppress inflammatory and immune responses By modulating cytokine production and inhibiting interleukin (IL) signaling pathways dexamethasone acetate serves as an interleukin receptor modulator Typically applied in research related to inflammation autoimmune diseases and cytokine-mediated cellular events it is extensively utilized in functional assays to understand receptor-ligand interactions signal transduction and therapeutic mechanisms Studies report variable IC50 values depending on cell type and assay conditions with typical IC50 ranges documented from 1-10 nM in receptor binding assays providing a reference concentration range for experimental designs
Apexbio Technology LLC Estradiol 50-28-2 10mM (in 1mL DMSO)
Estradiol is an endogenous steroid hormone involved in the regulation of reproductive biology and cellular physiology through interaction with estrogen receptor (ER) subtypes and Estradiol binding to ER initiates genomic and non-genomic signaling pathways influencing transcription of diverse target genes related to proliferation differentiation and metabolism Estradiol-mediated ER signaling modulates cellular processes including epithelial-mesenchymal transition endothelial function oxidative stress responses and gene expression profiles in various cell lines such as HEK293 and U2OS Additionally estradiol treatment regulates cardiovascular function by inducing mitochondrial superoxide dismutase (SOD2) implicating protective effects in vascular conditions Estradiol exhibits ER subtype selectivity with reported ER and ER binding affinities (IC50) around 0 2-0 5 nM utilized broadly in estrogen signaling research and cardiovascular disease modelling
Sigma Aldrich Fine Chemicals Biosciences Dexamethasone | 50-02-2 | MFCD00064136 | 500mg
Dexamethasone | Purity: 97% | Mol Wt: 392.46 | 50-02-2 | MFCD00064136 | 500mg